L'Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS UMR_S 1072), dirigée par Dominique Debanne, est une unité de recherche mixte sous la tutelle de l'INSERM (@Inserm) et de l'Université d'Aix-Marseille (@univamu).

L’Unité mono-équipe est organisée en 2 axes de recherche dont l'objectif principal est de comprendre le rôle des canaux ioniques dans la communication neuronale, la plasticité et les maladies du cerveau. L'unité abrite également une plateforme technologique qui 
vise à développer et proposer des outils moléculaires pour le diagnostic et le pronostic de maladies neurologiques. Nous proposons notamment un service de dosage d'auto anticorps dirigés contre les canaux calciques (VGCC) . 
2021 - Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit

2021 - The protein-binding pocket of Botulinum neurotoxin B accommodates a preassembled synaptotagmin / ganglioside complex

2021 - Gene Therapy Strategy for Alzheimer's and Parkinson's Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells

2021 - Mechanisms of plasticity in subcortical visual areas

2021 - A stable proportion of Purkinje cell inputs from parallel fibers are silent during cerebellar maturation

2021 - Endocannabinoids tune intrinsic excitability in O-LM interneurons by direct modulation of post-synaptic Kv7 channels

2021 - Therapeutic and Vaccine Strategies for Stopping the COVID-19 Pandemic Based on Structural and Molecular Modeling Studies of Virus-Ganglioside Interactions

2021 - Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

2021 - Formin activity and mDia1 contribute to maintain axon initial segment composition and structure

2021 - Calcium and spike timing-dependent plasticity

2021 - Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease

2021 - Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons

2021 - Ion Channel Degeneracy, Variability, and Covariation in Neuron and Circuit Resilience

2021 - Structural dynamics of SARS-CoV-2 variants: A health monitoring strategy for anticipating Covid-19 outbreaks

2021 - Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19

2021 - Neural excitability increases with axonal resistance between soma and axon initial segment

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Notre unité accueille régulièrement des stagiaires (L, ...Lire la suite