PUBLICATIONS

Chercher par auteur :
Tous les AuteursAlcaraz GAmendola JAnkri NAziz AAzzaz FBaudot PBialowas ABoudkkazi SBoumedine NBrechet ACaillard OCampanac ECarlier EChahinian HCoq JOCudmore RHDaoudal GDe San Feliciano MDebanne DDebreux KDenis DDesplantes RDi Giovanni JDubruc FDufour MDuménieu MDéglise PEl Far OExtrémet JFantini JFormisano-Treziny CFronzaroli-Molinieres LFékété AGabert JGasselin CGastrein PGiraud PGoaillard JMHaddjeri-Hopkins AIborra CIncontro SInglebert YLEVEQUE CLopez CLévêque CMarcaggi PMarqueze BMarra VMaulet YMoubarak EMoutot NRama SRamirez-Franco JJRussier MSammari MSangiardi MSeagar MSourdet VTapia MTell FTemporal SUsseglio FWakade AWoodhouse AYahi NYoussouf FZanin EZbili M

Chercher par année de publication :
Toutes les Années2023202220212020201920182017201620152014201320122011201020092008200720062005200420032002200120001999199819971996199519941993199219911990198919881987198619841983198219811980197919781974

Chercher par mot-clé :

	PUBLICATIONS
ACCUEIL   |  PUBLICATIONS

ANNEE : 2022

Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons

AUTEURS : Sammari M, Inglebert Y, Ankri N, Russier M, Incontro S, Debanne D.

REVUE : Proceedings of the National Academy of Sciences USA
Brain oscillations have long-lasting effects on synaptic and cellular properties. For instance, synaptic stimulation at theta (θ) frequency persistent depression of both excitatory synaptic transmission and intrinsic excitability in CA1 principal neurons. However, the incidence of θ activity on synaptic transmission and intrinsic excitability in hippocampal GABAergic interneurons is unclear. We report here the induction of both synaptic and intrinsic potentiation in oriens-lacunosum moleculare (O-LM) interneurons following stimulation of afferent glutamatergic inputs in the θ frequency range (~5 Hz). Long-term synaptic potentiation (LTP) is induced by synaptic activation of calcium-permeable AMPA receptors (CP-AMPAR), whereas long-term potentiation of intrinsic excitability (LTP-IE) results from the mGluR1-dependent down-regulation of Kv7 voltage-dependent potassium channel and hyperpolarization activated and cyclic nucleotide-gated (HCN) channel through the depletion of phosphatidiylinositol-4,5-biphosphate (PIP2). LTP and LTP-IE are reversible, demonstrating that both synaptic and intrinsic changes are bidirectional in O-LM cells. We conclude that synaptic activity at θ frequency induces both synaptic and in intrinsic potentiation in O-LM interneurons, i.e., the opposite of what is typically seen in glutamatergic neurons.